Full-thickness dorsal skin wounds in mice were treated with Noviogel for 3 and 7 days. No foreign body reaction, but even a significant decrease in granulocyte population in the worund was observed.
Noviogel hydrogels can be crosslinked after cell or organoid culture without loss of the reversible thermosensitive property during culture.
Op dit moment is Noviocell voor de ontwikkeling van Noviogel volgens Van den Dolder vooral op zoek naar investeerders om de stap naar het ontwikkelen van diagnostische 3D modellen te maken.
This recent study published in Acta Biomaterialia (2018) confirms that fibroblasts, endothelial cells, adipose-derived stem cells and melanoma cells, do survive, thrive and differentiate in optimized PIC hydrogels. They support the spontaneous formation of complex structures like blood capillaries in vitro.
• Syntrix-BM is highly transparent and compatible with multiple staining dyes and protocols employed in High Content Analysis, including stains for live cell analysis.
• Syntrix-BM supports High Content Analysis of cytotoxicity in a realistic 3D environment
• Syntrix-BM supports formation and analysis of 3D microtissues
A newer approach for cell retrieval is based on temperature-responsive polymers, which reversibly alter their hydrophobic/hydrophilic nature in response to cultivation temperature.