Researchers at Maastricht University, Noviocell BV and Cell Guidance Systems Ltd are collaborating on an EU funded Eurostars project to develop fully-defined matrices for the 3D culture of organoids.
Complex diseases like cancer are more frequently being modelled using in vitro systems as more researchers opt for three-dimensional (3D) cell culture methods over two-dimensional (2D) ones. In some cases, 3D systems even have advantages over tumour xenograft models .
Cell biologists are slowly replacing two-dimensional (2D) cell culture with more advanced alternatives, such as growing cells in three-dimensions (3D) by their encapsulation in hydrogels. Unlike 2D cell culture, where cells adhere to the culture vessel’s flat, hard surfaces in monolayers, 3D systems facilitate a higher order of cellular spatial organization and thus yield more physiologically relevant information – a definite advantage if you are looking to put a potential therapeutic molecule through its paces.
NovioCell CEO Juliette van den Dolder van Noviocell verwacht dat ze hun gepatenteerde hydrogeltechnologie volgend jaar al op de markt kunnen brengen. Deze biedt voor onderzoekers de mogelijkheid om cellen in 3D te laten groeien. Dit kan al wel, maar het grote voordeel van de nieuwe gel is dat deze synthetisch en aanpasbaar is in stijfte en elasticiteit. zie pagina 15
In January, Noviocell opened its office and laboratory at Pivot Park. The first colleague that Juliette van den Dolder (CEO) appointed for Noviocell was Onno van den Boomen (Senior Scientist). She asked him to share his personal experiences during the first three months.
3D culture in naturally derived hydrogels such as Matrigel or collagen matrices has shown to drive cellular self-organization and complex morphogenetic processes to result in sophisticated in vitro models. However, current methods mostly rely on natural derived materials that fail to enable fine and controlled manipulation of matrix parameters and culture conditions.
The brain-in-a-jar is one of science fiction’s creepier ideas. It is a safe prediction that 2016 will not see such literally disembodied people become reality. What it will see, though, is the blossoming of a technology that lets scientists grow things resembling brains—and also livers, kidneys, intestines and many other body parts—in glass vessels in laboratories.